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… Identifying causal biological mechanisms in ME/CFS by a functional genetic approach ME/CFS Chronic diseases DNA Fatigue Fri, 09/01/2023 - 12:00 - Wed, 09/01/2027 - … a serious and chronic disease whose cause is still unknown. This project aims to discover which genetic (DNA) variations are involved in ME/CFS. We also want to identify genes and biological … Other Extensive collaborations and Open Science are essential in research and especially in genetics and DNA research. Therefore, all outcomes will be published in an accessible manner. …

… Genetic Risk factors for Multi-system Inflammatory Syndrome in Children and Pediatric Long COVID … infection with SARS-CoV-2. STUDY DESIGN WP 1: WES to detect rare, high impact immunological genetic variants in MIS-C and post-COVID condition. We will perform Whole Exome Sequencing (WES) … Genetic Risk factors for Multi-system Inflammatory Syndrome in Children and Pediatric Long COVID …

… is no cure for dementia yet, which means that prevention is important. The risk factors include genetic risk factors as well as modifiable risk factors that a person can change, such as smoking. We fund projects aimed at prevention and risk reduction of dementia. Genetic and other risk factors for dementia A cohort study is one of the methods used to conduct …

… development of ME/CFS? And what genes, proteins and bodily processes should we be looking at? Geneticist Cindy Boer of Erasmus Medical Centre hopes to answer these questions in her ME/CFS study, which aims to identify the genetic basis for the disease. She believes this will enhance the prospects for treatment. 26 … deliver. A new blog will be published each month; this is the third in the series.. ME/CFS and genetics For a better understanding of ME/CFS, we have to look beyond visible symptoms. Things …

… the programme ZonMw Open Competition. The research groups will investigate, for example, the genetic factors of heart muscle diseases, better treatment of damage to the retina and the … disease, affecting approximately 180,000 people in the Netherlands. Treating childhood-onset genetic epilepsies is challenging. This project brings together researchers with expertise in … network function in epilepsy, using human brain tissue and human cell models. New energy for genetic cardiomyopathy Prof. ir J.P.W.M. (Jeroen) Bakkers – Hubrecht Institute Prof. F.W. …

… patients. Thanks to whole gene sequencing, doctors can now treat their patients based on their genetic makeup. That is not only good news for the patient but also medical science, says Edwin … at least once every three years somewhere in your body’, says Edwin Cuppen, Professor of Human Genetics at the University Medical Center Utrecht and principal investigator at the Oncode …

… disease or develop Long COVID. Emmeline and Suzanne wonder whether, and to what extent, genetic factors play a role. ZonMw is funding the study. 22 June 2023 Fortunately, most children … fairly unnoticed. We examine why this group of children is susceptible to MIS-C or Long COVID. Genetic variants In the case of MIS-C, the immune system seems to be deregulated. We think that …

… whilst others do not? The environment we live in certainly plays an important role here, but genetic characteristics are also key. Healthy Diet for a Healthy Life (HDHL) is funding research … and insulin resistance), making them an important risk factor for the diseases mentioned. Genetic and epigenetic factors also play a role in the development of disorders like obesity and …

… and treating SORL1-associated Alzheimer’s disease (SORLA - FIX) Dementia Alzheimer's disease Genetics Brain Wed, 07/01/2020 - 12:00 - Sat, 07/01/2023 - 12:00 733051110 SORL1 is an essential …

… of pathways linking aging and Alzheimer’s disease to cognitive decline and dementia Dementia Genetics Brain Neurology Elderly Mon, 04/01/2024 - 12:00 - Wed, 03/31/2027 - 12:00 … Alzheimer's disease and have subsequent effects on cognitive decline. By combining extensive genetic, gene expression, sequencing, proteomics, and phenotypic data, the researchers will …

… where larger parts of the disease course runs before dementia including pre-clinical periods. Genetic risks and early disease pathways (mechanisms and cellular responses) differ between AD … disease.  Approach Interestingly, inflammation and synapse loss are linked to premorbid genetic predispositions, and proteomic changes in cerebrospinal fluid and blood, and imaging …

… is, how they perform this role and finally how we can keep our gut microbes healthy. Interative genetic scoring for personalised risk assessment of Familial Hypercholesterolaemia Dr A.J. … can lead to cardiovascular complications in some individuals. Next to diet and medication, genetics play a significant role in determining these outcomes. This study examines to what …