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results found for 'Tuberculosis'.
- Project descriptionMycobacterium tuberculosis is the causative agent of tuberculosis (TB), a disease responsible for almost 1.5 million deaths per year. In recent years, different classes of drug resistant strains have emerged, making the discovery of novel tuberculostatic drugs a major priority. A major disadvantage of most existing and new TB compounds is that they target a single molecule…
- Infections caused by bacteria resistant to most antibiotics (so-called multidrug resistant bacteria) remain a global problem. The lack of new antibiotics is a major social problem and threat to human and animal health.AimIn this antimicrobial discovery project, researchers focused on developing novel antibiotics for the highly virulent and antibiotic-resistant human pathogens (called the ESKAPE…
- Bacteria can become resistant against beta-lactam antibiotics (Penicillin) by replacing their 3-4 peptide crosslinks by 3-3 crosslinks in the peptidoglycan layer in their cell wall that gives the bacterium its shape and protects it against mechanical stress. Peptidolglycan consists of a network of sugars strands that are interconnected by peptide crossbridges. Hardly anything was known about the…
