Zoeken op ZonMw

… person develops the disease. Some studies, like cohort studies of twins or families, show that DNA probably plays a role in ME/CFS. In other words, someone can have certain genetic variations in their DNA that increase their chances of developing ME/CFS in response to an external trigger. As soon … than someone who does not have these variations, or has fewer variations. It is estimated that DNA accounts for 30 to 50% of an individual’s risk of getting ME/CFS. I expect that we are able …

… of that is entering the clinic to improve the treatment of patients’. ‘Every letter from you r DNA mutates at least once every three years somewhere in your body’, says Edwin Cuppen, … development of cancer and in so doing aims to improve the treatment of patients. Recipe book DNA, our molecular recipe book, can be found in every cell of the body. It contains all the … and thymine. But just like during the repeated copying of a recipe, during the copying of the DNA, errors can occur between the letters, and mistakes can happen due to external factors such …

… a member. ‘This is a fantastic collaboration’, says Versteeg. ‘Together we have determined the DNA sequence and other features of hundreds of neuroblastomas. We now know for example that this … enormous amount’, so it now contains a huge collection of data on tumours. Not only about their DNA and RNA, but also their epigenetics: the histones that surround the DNA and determine whether or not it is activated.  ‘We hope we will eventually find a way to get …

… we still lack an unequivocal understanding of this Emmeline Buddingh Paediatric immunologist DNA from the saliva For this GRIP study, we recruited children with MIS-C from the COPP study, … a hundred children who have had MIS-C and a hundred children with Long COVID. We compare their DNA with the DNA of the control group: children who have had COVID-19, but did not develop MIS-C or Long …

… to identify what knowledge is needed, fund research and enhance impact. Collaboration is in our DNA ZonMw often connects different parties in the world of health, social welfare and care. Working with others is in our DNA. It is only by collaborating with others in various fields that we can achieve our mission – …

… exist and they collectively impact a significant portion of the population. Advances in DNA sequencing technologies have recently improved the diagnostic yield for these conditions. … further diagnostic gains a challenge. In this project, I will systematically investigate how DNA differences affect isoforms, and I will utilize this knowledge to identify which DNA alteration is responsible for rare diseases in more patients. Prenatal Family Integrated …

… liver. In this project, we aim to develop a genomics-based predictor using gene expression and DNA methylation data. This tool will help improve the selection of donor livers suitable for … a blood cancer that remains extremely difficult to treat. AML is caused by aberrations in the DNA, which disturb the normal differentiation process from hematopoietic stem cells to mature … thereby forming so-called transcriptional condensates, which are gel-like structures on the DNA. The main aim of the current proposal is to dissect the composition and function of these …

… cause of intestinal infections and is found in water and various animals, where the bacterial DNA is threatened by invasion of DNA from other microorganisms, bacteriophages or plasmids. The adaptive immune system (CRISPR-Cas) protects DNA from this threat. By linking spacers to the source, we will investigate how CRISPR dynamics …

… University, Department of Bioengineering -> 24 months All cells in our body share the same DNA, still there are great differences between a muscle cell or a neuron. This is determined by …