Diseased cardiomyocytes from human stem cells for drug repurposing and safety pharmacology.

Titel: Invited speaker at Dutch-German Molecular Cell Cardiology Meeting
Auteur: Bellin M

Titel: Invited speaker at Stem Cell Research Italy, Genova, IT
Auteur: Bellin M

Titel: HiPSC-derived three-dimensional cardiac microtissues to study the contribution of cardiomyocytes and cardiac fibroblasts in Arrhythmogenic Cardiomyopathy pathogenesis
Auteur: Meraviglia V, Campostrini G, Cochrane A, Ward-van Oostwaard D, Sommariva E, Pompilio G, Mummery CL, Bellin M

Titel: Ascona International Workshop on Cardiomyocyte Biology, Ascona, Switzerland
Auteur: Bellin M

Titel: Three-dimensional cardiac microtissues composed by hiPSC-derived cells induce electrophysiological maturation of cardiomyocytes
Auteur: Campostrini G, Giacomelli E, Meraviglia V, Cochrane A, Tertoolen LGJ, Semrau S, Orlova V, Mummery CL, Bellin M

Titel: Advanced course on Derivation of hiPSC, Wellcome Genome Campus, Hinxton, UK
Auteur: Bellin M

Titel: Webinar Interreg “Cardio protection and Arrhythmia”
Auteur: Bellin M

Titel: HiPSC-derived three-dimensional cardiac microtissues to study the contribution of cardiomyocytes and cardiac fibroblasts in Arrhythmogenic Cardiomyopathy pathogenesis
Auteur: Meraviglia V, Campostrini G, Cochrane A, Ward-van Oostwaard D, Sommariva E, Pompilio G, Mummery CL, Bellin M

Titel: Invited lecture at EURAC Research, Bozen, Italy. Host: Dr. A. Rossini
Auteur: Bellin M

Titel: Kcnq1 residual paternal-allele imprinting in hipsc-derived cardiomyocytes is lost upon maturation in tri-cellular cardiac microtissues revealing mutation effects
Auteur: Campostrini G, Ward-van Oostwaard D, Verkerk AO, Mummery CL, Bellin M

Titel: Advanced course on Genetic engineering of mammalian stem cells, Wellcome Genome Campus, Hinxton, UK
Auteur: Bellin M

Titel: Tri-cellular cardiac microtissues from hipscs model post-natal and multicellular cardiac arrhythmic disease
Auteur: Meraviglia V, Campostrini G, Ward-van Oostwaard D, Mummery CL, Bellin M

Titel: Keynote Speaker at the 9th Rembrandt Symposium for Cardiovascular Science, NL
Auteur: Bellin M

Titel: Invited lecture at University of Padova, Italy. Host: Prof. G. Lanfranchi
Auteur: Bellin M

Titel: Invited lecture at Centro Cardiologico Monzino, Milan, Italy. Host: Prof. G. Pompilio
Auteur: Bellin M

Titel: Invited speaker at European Muscle Conference, online
Auteur: Bellin M

Titel: Cardiac microtissues from hiPSCs: an improved model for human heart
Auteur: Campostrini G, Ward-van Oostwaard D, Mummery CL, Bellin M

Titel: Invited speaker at Dutch Organ-on-chip consortium hDMT (human organ and disease model technologies), Heart on Chip group meeting, Amsterdam (NL), 2018
Auteur: Bellin M

Titel: Maturation of hiPSC-derived cardiomyocytes promotes adult alternative splicing of SCN5A and reveals changes in sodium current associated with cardiac arrhythmia
Auteur: Campostrini G, Kosmidis G, Ward-van Oostwaard D, Verkerk AO, Bezzin CR, Mummery CL, Bellin M

Titel: Setting up of a drug screening platform based on isogenic human iPSC-derived cardiomyocytes
Auteur: Campostrini G, Sala L, van Meer BG, Ward-van Oostwaard D, Tertoolen LGJ, Bartulos-Encinas O, Braam SR, IJzerman AP, Mummery CL, Bellin M

Titel: Keynote Speaker, Italian Society for Cardiovascular Research, Imola, IT
Auteur: Bellin M

Titel: Invited talk at Veneto Institute of Molecular Medicine, Padova (IT), 2018
Auteur: Bellin M

Titel: Generation of three human induced pluripotent stem cell lines, LUMCi024-A, LUMCi025-A, and LUMCi026-A, from two patients with combined oxidative phosphorylation deficiency 8 and a related control
Auteur: van Helden RWJ, Birket MJ, Freund C, Arendzen CH, Mikkers HM, Orlova V, de Coo RI, Mummery CL, Bellin M
Magazine: Stem Cell Research

Titel: Maturation of hiPSC-derived cardiomyocytes promotes adult alternative splicing of SCN5A and reveals changes in sodium current associated with cardiac arrhythmia
Auteur: Campostrini G, Kosmidis G, Ward-van Oostwaard D, Davis RP, Yiangou L, Ottaviani D, Veerman CC, Mei H, Orlova VV, Wilde AAM, Bezzina CR, Verkerk AO, Mummery CL, Bellin M
Magazine: Cardiovascular Research

Titel: Generation of human induced pluripotent stem cell line EURACi006-A and its isogenic gene-corrected line EURACi006-A-1 from an arrhythmogenic cardiomyopathy patient carrying the c.1643delG PKP2 mutation
Auteur: Meraviglia V, Ganesh S, Arendzen CH, Freund C, Sommariva E, Rossini A, Bellin M
Magazine: Stem Cell Research

Titel: MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo
Auteur: Sala L, van Meer BJ, Tertoolen LGJ, Bakkers J, Bellin M, Davis RP, Denning C, Dieben MAE, Eschenhagen T, Giacomelli E, Grandela C, Hansen A, Holman ER, Jongbloed MRM, Kamel SM, Koopman CD, Lachaud Q, Mannhardt I, Mol MPH, Mosqueira D, Orlova VV, Passier R, Ribeiro MC, Saleem U, Smith GL, Burton FL, Mummery CL
Magazine: Circulation Research
Begin- en eindpagina: 5-16
Link: http://circres.ahajournals.org/content/122/3/e5.long

Titel: Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease
Auteur: Giacomelli E, Meraviglia V, Campostrini G, Cochrane A, Cao X, van Helden RWJ, Krotenberg Garcia A, Mircea M, Kostidis S, Davis RP, van Meer BJ, Jost CR, Koster AJ, Mei H, Míguez DG, Mulder AA, Ledesma-Terrón M, Pompilio G, Sala L, Salvatori DCF, Slieker RC, Sommariva E, de Vries AAF, Giera M, Semrau S, Tertoolen LGJ, Orlova VV, Bellin M, Mummery CL.
Magazine: Cell Stem Cell

Titel: Generation, functional analysis and applications of isogenic three-dimensional self-aggregating cardiac microtissues from human pluripotent stem cells
Auteur: Campostrini G, Meraviglia V, Giacomelli E, van Helden RWJ, Yiangou L, Davis RP, Bellin M, Orlova VV, Mummery CL
Magazine: Nature Protocols

Titel: Targeting the Kv11.1 (hERG) channel with allosteric modulators. Synthesis and biological evaluation of three novel series of LUF7346 derivatives
Auteur: Jacobus P.D. van Veldhoven, Giulia Campostrini, Constantijn J.E. van Gessel, Dorien Ward-van Oostwaard, Rongfang Liu, Christine L. Mummery, Milena Bellin, Adriaan P. IJzerman a
Magazine: European Journal of Medicinal Chemistry
Begin- en eindpagina: 1-13
Link: https://doi.org/10.1016/j.ejmech.2020.113033

Titel: Toward Human Models of Cardiorenal Syndrome in vitro
Auteur: Gabbin B, Meraviglia V, Mummery CL, Rabelink TJ, van Meer BJ, van den Berg CW, Bellin M
Magazine: Frontiers in Cardiovascular Medicine

Titel: Desmosomal protein degradation as an underlying cause of arrhythmogenic cardiomyopathy
Auteur: Tsui H, van Kampen SJ, Han SJ, Meraviglia V, van Ham WB, Casini S, van der Kraak P, Vink A, Yin X, Mayr M, Bossu A, Marchal GA, Monshouwer-Kloots J, Eding J, Versteeg D, de Ruiter H, Bezstarosti K, Groeneweg J, Klaasen SJ, van Laake LW, Demmers JAA, Kops GJPL, Mummery CL, van Veen TAB, Remme CA, Bellin M, van Rooij E
Magazine: Science Translational Medicine

Titel: Cardiac microtissues from human pluripotent stem cells recapitulate the phenotype of long-QT syndrome
Auteur: Giacomelli E, Sala L, Oostwaard DW, Bellin M
Magazine: Biochemical and biophysical research communications

Titel: Integrated Proteomics Unveils Nuclear PDE3A2 as a Regulator of Cardiac Myocyte Hypertrophy
Auteur: Subramaniam G, Schleicher K, Kovanich D, Zerio A, Folkmanaite M, Chao YC, Surdo NC, Koschinski A, Hu J, Scholten A, Heck AJR, Ercu M, Sholokh A, Park KC, Klussmann E, Meraviglia V, Bellin M, Zanivan S, Hester S, Mohammed S, Zaccolo M
Magazine: Circulation Research

Titel: Inflammation in the Pathogenesis of Arrhythmogenic Cardiomyopathy: Secondary Event or Active Driver?
Auteur: Meraviglia V, Alcalde M, Campuzano O, Bellin M
Magazine: Frontiers in Cardiovascular Medicine

Titel: Cardiac Tissues From Stem Cells: New Routes to Maturation and Cardiac Regeneration
Auteur: Campostrini G, Windt LM, van Meer BJ, Bellin M, Mummery CL
Magazine: Circulation Research

Titel: bulk RNA sequencing data from hiPSC-derived cardiac microtissues and standard 2D cardiomyocytes
Link: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE116464

Titel: single-cell RNA sequencing data from hiPSC-derived cardiac microtissues and standard 2D cardiomyocytes
Link: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147694

Titel: bulk RNA sequencing data from hiPSC-derived cardiac microtissues and standard 2D cardiomyocytes from SCN5A mutant line and isogenic corrected line
Link: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE180290

Titel: corrected isogenic hiPSC cell line registration from a PKP2 mutant patient affected by arrhythmogenic cardiomyopathy
Link: https://hpscreg.eu/cell-line/LUMCi027-A-1

Titel: hiPSC cell line registration from a PKP2 mutant patient affected by arrhythmogenic cardiomyopathy
Link: https://hpscreg.eu/cell-line/LUMCi027-A

Titel: hiPSC cell line registration from a SCN5A mutant patient affected by severe conduction abnormalities
Link: https://hpscreg.eu/cell-line/LUMCi040-A

Titel: Long-QT 1 patient hiPSC cell line registration
Link: https://hpscreg.eu/cell-line/LUMCi039-A

Titel: hiPSC cell line registration from a healthy individual
Link: https://hpscreg.eu/cell-line/LUMCi028-A

Titel: Best presentation Young Investigator award at Frontiers in Cardiovascular Biomedicine meeting to Giulia Campostrini