Targeting Western Diet-Induced Neurodegeneration

Although life expectancy has increased globally, many of us spend these additional years in poorer health, with dementia being one of the conditions that has a significant impact as we age. Additionally, the 'Western diet' is known to cause classic lifestyle diseases such as obesity and atherosclerosis. Recent research has shown that the 'Western diet' also activates the fat Sphingomyelin (S14), leading to inflammatory reactions and brain damage.

Objective

With an international research team, we aim to investigate whether S14 and other fats act as the link between our Western diet, obesity, and the onset of dementia.

Approach

We will examine S14 and other fats in the blood and cerebrospinal fluid of people with and without dementia. Additionally, we will investigate in mouse models whether blocking S14 reduces inflammation and brain damage.

Expected Results

This research may provide new insights and treatment options for dementia.