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results found for 'Bacteriën'.
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Bacteria can become resistant against beta-lactam antibiotics (Penicillin) by replacing their 3-4 peptide crosslinks by 3-3 crosslinks in the peptidoglycan layer in their cell wall that gives the bacterium its shape and protects it against mechanical stress. Peptidolglycan consists of a network of sugars strands that are interconnected by peptide crossbridges. Hardly anything was known about the…
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The emergence of antibiotic resistance is increasingly limiting treatment of bacterial infections. Bacteria can become resistant via a process called “horizontal gene transfer (HGT)” which enable bacteria to exchange DNA that may include resistance genes. AimThis project studies the ways in which resistant bacteria can evolve in complex ecosystems, in which they can acquire genetic material that…
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Resistance against β-lactam antibiotics is a serious health issue. Often it is caused by bacteria producing enzymes capable of inactivating these antibiotics, β-lactamases. This can be prevented by combining the antibiotic with a compound able to inhibit the bacterial enzyme. AimThe aim of this project was to find new β-lactamase inhibitors. To achieve this a large botanical extract library was…
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Researchers propose the FunHitDisco, a Fungal Hit Discovery Platform. Read how they will use this to discover antifungal drugs.
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Read how the COMBAT-AMR project will develop a standardised toolbox specifically for designing antibiotic combination treatments.
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Researchers will determine the effectiveness of antibiotic stewardship programs in the intensive care unit and formulate recommendations for implementation.
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The project aims to provide broad insight into current risk factors for primary invasive Group A Streptococcus and the effect of the recently-expanded antibiotic prophylaxis guideline to prevent secondary iGAS infections.
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Read how researchers will create an implementation tool to improve compliance with infection prevention measures by physicians in hospitals.
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Researchers will work with out-of-hour primary care services to create a national learning community to reduce antibiotic prescriptions.
- Project descriptionResistance to antibiotics is increasing worldwide and alternatives are sought for antimicrobial treatment. AimThe overall purpose was to explore and identify antibiotics and non-antibiotics more active in combination than alone (called synergism) against multi- drug resistant bacteria. The tasks of the EMC involved the overall coordination of the project, identification of…
