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… Dr J. (Jeffrey) Kroon, Stichting Amsterdam UMC This project explores the critical role of inflammation in heart and vascular diseases and focuses on tuning our immune system through … in how our blood vessel cells function. These 'gatekeepers' can either promote or reduce inflammation, thus providing an opportunity to enhance the response of our immune system, our … us. Researchers seek to find evidence how key environmental sensors in our skin can influence inflammation, particularly in response to our diet and the microorganisms residing on our skin. …

… after sepsis: a record linkage study Infectious disease Chronic condition  Infection prevention Inflammations Fri, 03/01/2024 - 12:00 - Sun, 03/01/2026 - 12:00 10150022310012 Approximately …

… dementia. Additionally, we will investigate in mouse models whether blocking S14 reduces inflammation and brain damage. Expected Results This research may provide new insights and …

… MICro-brains: An animal-free human 3D cortical network platform for screening myelination and inflammation phenotypes. 3D Myelination & Inflammation Cortical network platform (3D MICro-brains) - Dr Femke de Vrij (Erasmus MC) Private …

… reason for hospitalization, are being treated with dexamethasone, regardless of their level of inflammation, severity of disease (COVID-19 on the ward to COVID-associated ARDS; C-ARDS) or way … they assess the need of ICU-therapy as dexamethasone failure or as a marker of higher level of inflammation. Intervention: After 10 days of dexamethasone therapy patients are being stratified … is characterized by an initial phase of viral pneumonia followed by immunothrombosis and hyperinflammation to diffuse alveolar damage or organising pneumonia eventually ending with fibrosis …

… also investigate how nerve cells and immune cells work together to actively turn off pain after inflammation. This knowledge helps the development of therapies against chronic pain.These are …

… who were overweight and/or had a chronic medical condition The Role of Overweight in Amplifying Inflammation and Organ Failure (available in Dutch) project is currently investigating the …

… on the patients’ blood profiles at the time of infection, as well as six weeks later, measuring inflammation markers, immune cells, DNA profiles and protein levels.  These values will give us … see the same physical mechanisms, such as a worsening of symptoms after exertion. I think that inflammation processes in the brain have a role in this. So it is important to look into the …

… brain and reflect disease processes related to Alzheimer's disease.  Approach Interestingly, inflammation and synapse loss are linked to premorbid genetic predispositions, and proteomic …

… it has been shown that the dura mater is an immunological active hub, involved in brain inflammation and cancer. At least, that was shown in murine models. Thus far, knowledge on dura … antibodies for the treatment of psoriasis. Psoriasis is an autoimmune disease in which chronic inflammation of the skin takes place. Current medication consists out of antibodies against … the immune system through the entire body and not only at the sites of psoriasis related inflammation. In this project we will perform the first steps towards a TNF-alpha antibody that …

… role of iron in the worsening of multiple sclerosis Multiple sclerosis (MS) is a disease where inflammation damages the brain and spinal cord. Researchers will study how iron build-up in …

… disease Dr M.C. Barnhoorn, Leiden UMC Crohn's disease, characterized by chronic intestinal inflammation, is currently treated by inhibiting the immune cells in the intestine. However, … MC Immune checkpoint inhibitors (ICI) are effective cancer drugs. Unfortunately, they can cause inflammation of the heart, myocarditis. Currently, there is no strategy for identifying patients … models for pancreatic cancer. Beyond Skin: Revealing the hidden connection between skin and gut inflammation. Dr K.R. van Straalen, Erasmus MC Hidradenitis suppurativa (HS) is a chronic skin …