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results found for 'Resistentie'.
- Afbeelding
Antimicrobial resistance affects human and animal health because it causes untreatable infections. Read which research ZonMw is funding. - Afbeelding
Read how ZonMw develops and disseminates evidence-based knowledge of infectious disease to reduce the burden of disease and its impact on society. - The rapid spread of multidrug resistant bacteria threatens the treatment of even simple infections in the near future. However, little is known about how bacteria develop resistance on surfaces.AimThe aim of this project was to investigate fundamental mechanisms that shape antimicrobial resistance in biofilms in relation to the surface and then translate those findings into clinical practice…
- Urgent action is required to stem the spread of antimicrobial resistance (AMR). However, because the pace of novel drug development lags behind the evolution of novel AMR determinants, new strategies of containment are required.MethodIn this multinational project proposal, researchers have worked on a resistance-reversal strategy based on the concept of collateral sensitivity (CS). CS between a…
- Infections with antibiotic-resistant bacteria are a major threat to public health. Due to globalisation and poor use of antibiotics, resistance is spreading rapidly. Moreover, few new antibiotics have come onto the market in the last 20 years.AimIn this international project, researchers have been using the latest high-throughput screens to look for new combinations of drugs that can effectively…
- Investigations into Aspergillus fumigatus and the treatment are underway both nationally and internationally and will lead to advisory reports. This project will organize a stakeholder meeting to further results.
- Bacteria are increasingly becoming resistant to antibiotics. This is an immediate threat to health care in the Netherlands and elsewhere. Recent studies show that, in Europe alone, more than 30.000 individuals die every year due to an infection with an antibiotic-resistant bacterium.AimThis project studied the pathways by which resistant bacteria can emerge in complex ecosystems, in which they can…
- Read how this project gained more insight into the resistance mechanisms of pneumococci, particularly the environmental, immunological and pharmacological factors.
- Methicillin-resistant Staphylococcus aureus (MRSA) is characterised by clonal spread. MRSA clones are unequally distributed across the world and different clones are dominant at different times. AimThe MACOTRA project studied the interaction between MRSA, humans and the environment. The researchers used mathematical models to gain a better understanding of MRSA dynamics.ResultsA main predictor of…
- Resistance against β-lactam antibiotics is a serious health issue. Often it is caused by bacteria producing enzymes capable of inactivating these antibiotics, β-lactamases. This can be prevented by combining the antibiotic with a compound able to inhibit the bacterial enzyme. AimThe aim of this project was to find new β-lactamase inhibitors. To achieve this a large botanical extract library was…
- Researchers propose the FunHitDisco, a Fungal Hit Discovery Platform. Read how they will use this to discover antifungal drugs.
- Read how researchers will develop reliable biomarkers to improve treatment predictions and outcomes for antifungal-resistant Candida infections.