Personalized Care for Depression: Bringing Immuno-Metabolic Depression from Bench to Bedside
Depressie is geen ‘one-size-fits-all’ diagnose, maar kent vele vormen. Behandelingen zijn hier echter vaak niet op afgestemd, waardoor behandelsucces tegen valt. Meer gepersonaliseerde
zorg bij depressie is daarom noodzakelijk.
Immuno-metabole depressie
Ongeveer 25% van de mensen met depressie heeft kenmerken van 'immuno-metabole depressie'. Deze kenmerken zijn bijvoorbeeld een verhoogde eetlust, extreme moeheid, obesitas of verhoogde ontstekingswaarden.
Doel en werkwijze
Dit project draagt bij aan gepersonaliseerde zorg door te onderzoeken hoe immuno-metabole
depressie in de praktijk het best vastgesteld kan worden. Er wordt onderzocht welke behandelingen (daglicht, voeding, hardlopen, medicatie) het meest geschikt lijken voor mensen met kenmerken van immuno-metabole depressie. Daarnaast wordt samen met mensen met depressie gekeken naar wat zij nodig hebben om gepersonaliseerde depressiezorg te laten slagen.
Met deze kennis over immuno-metabole depressie, behandeling en patiënten-aanbevelingen kan gerichter worden behandeld, wat de kwaliteit en doelmatigheid van zorg kan verbeteren.
Producten
Titel: Features of immunometabolic depression as predictors of antidepressant treatment outcomes: pooled analysis of four clinical trials
Auteur: Sarah R. Vreijling, Cherise R. Chin Fatt, Leanne M. Williams, Alan F. Schatzberg, Tim Usherwood, Charles B. Nemeroff, A. John Rush, Rudolf Uher, Katherine J. Aitchison, Ole Köhler Forsberg, Marcella Rietschel, Madhukar H. Trivedi, Manish K. Jha, Brenda W. J. H. Penninx, Aartjan T. F. Beekman, Rick Jansen* and Femke Lamers*
Magazine: The British Journal of Psychiatry
Begin- en eindpagina: 89-97
Link: https://doi.org/10.1192/bjp.2023.148
Auteur: Sarah R. Vreijling, Cherise R. Chin Fatt, Leanne M. Williams, Alan F. Schatzberg, Tim Usherwood, Charles B. Nemeroff, A. John Rush, Rudolf Uher, Katherine J. Aitchison, Ole Köhler Forsberg, Marcella Rietschel, Madhukar H. Trivedi, Manish K. Jha, Brenda W. J. H. Penninx, Aartjan T. F. Beekman, Rick Jansen* and Femke Lamers*
Magazine: The British Journal of Psychiatry
Begin- en eindpagina: 89-97
Link: https://doi.org/10.1192/bjp.2023.148
Titel: The metabolome-wide signature of major depressive disorder
Auteur: Rick Jansen, Yuri Milaneschi, Daniela Schranner, Gabi Kastenmuller, Matthias Arnold, Xianlin Han, Boadie W Dunlop; Mood Disorder Precision Medicine Consortium; A John Rush, Rima Kaddurah-Daouk, Brenda Wjh Penninx
Magazine: Molecular Psychiatry
Link: https://doi.org/10.21203/rs.3.rs-3127544/v1
Auteur: Rick Jansen, Yuri Milaneschi, Daniela Schranner, Gabi Kastenmuller, Matthias Arnold, Xianlin Han, Boadie W Dunlop; Mood Disorder Precision Medicine Consortium; A John Rush, Rima Kaddurah-Daouk, Brenda Wjh Penninx
Magazine: Molecular Psychiatry
Link: https://doi.org/10.21203/rs.3.rs-3127544/v1
Titel: Dissection of depression heterogeneity using proteomic clusters
Auteur: Marije van Haeringen, Yuri Milaneschi, Femke Lamers, Brenda W J H Penninx, Rick Jansen
Magazine: Psychological Medicine
Link: https://doi.org/10.1017/s0033291721004888
Auteur: Marije van Haeringen, Yuri Milaneschi, Femke Lamers, Brenda W J H Penninx, Rick Jansen
Magazine: Psychological Medicine
Link: https://doi.org/10.1017/s0033291721004888
Titel: Effects of dietary interventions on depressive symptom profiles: results from the MooDFOOD depression prevention study
Auteur: Sarah R. Vreijling, Brenda W. J. H. Penninx , Mariska Bot , Ed Watkins, Matthew Owens, Elisabeth Kohls, Ulrich Hegerl, Miquel Roca, Margalida Gili, Ingeborg A. Brouwer, Marjolein Visser, Aartjan T. F. Beekman, Rick Jansen and Femke Lamers
Magazine: Psychological Medicine
Begin- en eindpagina: 3580-3589
Link: https://doi.org/10.1017/S0033291721000337
Auteur: Sarah R. Vreijling, Brenda W. J. H. Penninx , Mariska Bot , Ed Watkins, Matthew Owens, Elisabeth Kohls, Ulrich Hegerl, Miquel Roca, Margalida Gili, Ingeborg A. Brouwer, Marjolein Visser, Aartjan T. F. Beekman, Rick Jansen and Femke Lamers
Magazine: Psychological Medicine
Begin- en eindpagina: 3580-3589
Link: https://doi.org/10.1017/S0033291721000337
Titel: Depression with immuno-metabolic dysregulation: Testing pragmatic
criteria to stratify patients
Auteur: J C Zwiep, Y Milaneschi, E J Giltay, C H Vinkers, B W J H Penninx, F Lamers
Magazine: Brain Behavior Immunity
Link: https://doi.org/10.1016/j.bbi.2024.11.033
Auteur: J C Zwiep, Y Milaneschi, E J Giltay, C H Vinkers, B W J H Penninx, F Lamers
Magazine: Brain Behavior Immunity
Link: https://doi.org/10.1016/j.bbi.2024.11.033
Titel: The association between clinical and biological characteristics of depression and structural brain alterations
Auteur: Yara J. Toenders, Lianne Schmaal, Laura Nawijn, Laura K.M. Han, Julia Binnewies , Nic J.A. van der Wee e, Marie-Jose van Tol f, Dick J. Veltman,Yuri Milaneschi c, Femke Lamers, Brenda W.J.H. Penninx
Magazine: Journal of Affective Disorders
Link: https://doi.org/10.1016/j.jad.2022.06.056
Auteur: Yara J. Toenders, Lianne Schmaal, Laura Nawijn, Laura K.M. Han, Julia Binnewies , Nic J.A. van der Wee e, Marie-Jose van Tol f, Dick J. Veltman,Yuri Milaneschi c, Femke Lamers, Brenda W.J.H. Penninx
Magazine: Journal of Affective Disorders
Link: https://doi.org/10.1016/j.jad.2022.06.056
Titel: Immuno-metabolic depression: from concept to implementation
Auteur: Brenda W.J.H. Penninx, Femke Lamers · Rick Jansen · Michael Berk · Golam M. Khandaker· Livia De Picker · Yuri Milaneschi
Magazine: The Lancet Regional Health Europe
Link: https://www.zonmw.nl
Auteur: Brenda W.J.H. Penninx, Femke Lamers · Rick Jansen · Michael Berk · Golam M. Khandaker· Livia De Picker · Yuri Milaneschi
Magazine: The Lancet Regional Health Europe
Link: https://www.zonmw.nl
Titel: Sociodemographic, lifestyle and clinical characteristics of energy-related depression symptoms: A pooled analysis of 13,965 depressed cases in 8 Dutch cohorts
Auteur: Sarah R. Vreijling et al.
Magazine: Journal of Affective Disorders
Begin- en eindpagina: 1-9
Link: https://doi.org/10.1016/j.jad.2022.11.005
Auteur: Sarah R. Vreijling et al.
Magazine: Journal of Affective Disorders
Begin- en eindpagina: 1-9
Link: https://doi.org/10.1016/j.jad.2022.11.005
Titel: Metabolomics signatures of depression: the role of symptom profiles
Auteur: Hilde de Kluiver, Rick Jansen, Brenda W. J. H. Penninx, Erik J. Giltay, Robert A. Schoevers, Yuri Milaneschi
Magazine: Translational Psychiatry
Link: https://doi.org/10.1038/s41398-023-02484-5
Auteur: Hilde de Kluiver, Rick Jansen, Brenda W. J. H. Penninx, Erik J. Giltay, Robert A. Schoevers, Yuri Milaneschi
Magazine: Translational Psychiatry
Link: https://doi.org/10.1038/s41398-023-02484-5
Titel: The role of immuno-metabolic depression features in the effects of light therapy in patients with depression and type 2 diabetes mellitus: A randomized controlled trial
Auteur: Sarah R. Vreijling, Layla Neuhaus, Annelies Brouwer, Brenda W.J.H. Penninx, Aartjan T.F. Beekman, Femke Lamers, Rick Jansen, Marijke Bremmer
Magazine: Journal of Psychosomatic Research
Begin- en eindpagina: 1-7
Link: https://doi.org/10.1016/j.jpsychores.2024.111671
Auteur: Sarah R. Vreijling, Layla Neuhaus, Annelies Brouwer, Brenda W.J.H. Penninx, Aartjan T.F. Beekman, Femke Lamers, Rick Jansen, Marijke Bremmer
Magazine: Journal of Psychosomatic Research
Begin- en eindpagina: 1-7
Link: https://doi.org/10.1016/j.jpsychores.2024.111671
Titel: Running therapy or antidepressants as treatments for immunometabolic depression in patients with depressive and anxiety disorders: A secondary analysis of the MOTAR study
Auteur: Sarah R. Vreijling , Brenda W.J.H. Penninx, Josine E. Verhoeven, Charlotte E. Teunissen, Elena R. Blujdea, Aartjan T.F. Beekman, Femke Lamers, Rick Jansen
Magazine: Brain Behavior and Immunity
Begin- en eindpagina: 876-883
Link: https://doi.org/10.1016/j.bbi.2024.10.033
Auteur: Sarah R. Vreijling , Brenda W.J.H. Penninx, Josine E. Verhoeven, Charlotte E. Teunissen, Elena R. Blujdea, Aartjan T.F. Beekman, Femke Lamers, Rick Jansen
Magazine: Brain Behavior and Immunity
Begin- en eindpagina: 876-883
Link: https://doi.org/10.1016/j.bbi.2024.10.033
Titel: Linking atypical depression and insulin resistance-related disorders via
low-grade chronic inflammation: Integrating the phenotypic, molecular and
neuroanatomical dimensions
Auteur: Zümrüt Duygu Sen, Lena Vera Danyeli, Marie Woelfer, Femke Lamers, Gerd Wagner, Thomas Sobanski, Martin Walter
Magazine: Brain Becavior Immunity
Auteur: Zümrüt Duygu Sen, Lena Vera Danyeli, Marie Woelfer, Femke Lamers, Gerd Wagner, Thomas Sobanski, Martin Walter
Magazine: Brain Becavior Immunity
Titel: Antidepressants or running therapy: Comparing effects on mental and physical health in patients with depression and anxiety disorders
Auteur: Josine E. Verhoeven et al.
Magazine: Journal of Affective Disorders
Link: https://doi.org/10.1016/j.jad.2023.02.064
Auteur: Josine E. Verhoeven et al.
Magazine: Journal of Affective Disorders
Link: https://doi.org/10.1016/j.jad.2023.02.064