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resultaten gevonden voor 'Bacteria'.
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The emergence of antibiotic resistance is increasingly limiting treatment of bacterial infections. Bacteria can become resistant via a process called “horizontal gene transfer (HGT)” which enable bacteria to exchange DNA that may include resistance genes. AimThis project studies the ways in which resistant bacteria can evolve in complex ecosystems, in which they can acquire genetic material that…
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Bacteriophages and plasmids are often specific to a particular source, this project will investigate how CRISPR dynamics are related to environmental niche adaptation and recalibrate source attribution models.
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Read more about the research project on immune responses to against microbiota as biomarkers for ME/CFS.
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Bacteria can become resistant against beta-lactam antibiotics (Penicillin) by replacing their 3-4 peptide crosslinks by 3-3 crosslinks in the peptidoglycan layer in their cell wall that gives the bacterium its shape and protects it against mechanical stress. Peptidolglycan consists of a network of sugars strands that are interconnected by peptide crossbridges. Hardly anything was known about the…
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Resistance against β-lactam antibiotics is a serious health issue. Often it is caused by bacteria producing enzymes capable of inactivating these antibiotics, β-lactamases. This can be prevented by combining the antibiotic with a compound able to inhibit the bacterial enzyme. AimThe aim of this project was to find new β-lactamase inhibitors. To achieve this a large botanical extract library was…
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Researchers propose the FunHitDisco, a Fungal Hit Discovery Platform. Read how they will use this to discover antifungal drugs.
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Read how researchers will use genome sequencing to study the fungal genus Candida in hospitals to limit its transmission.
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Read how this project contributes to the implementation and updates of tools in long-term care.
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Researchers will determine the effectiveness of antibiotic stewardship programs in the intensive care unit and formulate recommendations for implementation.
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Read how the COMBAT-AMR project will develop a standardised toolbox specifically for designing antibiotic combination treatments.
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The project aims to provide broad insight into current risk factors for primary invasive Group A Streptococcus and the effect of the recently-expanded antibiotic prophylaxis guideline to prevent secondary iGAS infections.
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Vancomycin-resistant Enterococcus faecium (VRE) is a multi-resistant bacterium, capable of causing outbreaks in hospitals. This project aims to determine the best VRE screening protocol.