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results found for 'Resistance'.
- Read how the SHIELD-project strengthens natural defences through ‘trained immunity’, enabling the immune system to combat fungal infections more effectively.
- Researchers will determine the effectiveness of antibiotic stewardship programs in the intensive care unit and formulate recommendations for implementation.
- Read how researchers will use genome sequencing to study the fungal genus Candida in hospitals to limit its transmission.
- Project descriptionMycobacterium tuberculosis is the causative agent of tuberculosis (TB), a disease responsible for almost 1.5 million deaths per year. In recent years, different classes of drug resistant strains have emerged, making the discovery of novel tuberculostatic drugs a major priority. A major disadvantage of most existing and new TB compounds is that they target a single molecule…
- Bacteria can become resistant against beta-lactam antibiotics (Penicillin) by replacing their 3-4 peptide crosslinks by 3-3 crosslinks in the peptidoglycan layer in their cell wall that gives the bacterium its shape and protects it against mechanical stress. Peptidolglycan consists of a network of sugars strands that are interconnected by peptide crossbridges. Hardly anything was known about the…
- Resistance against β-lactam antibiotics is a serious health issue. Often it is caused by bacteria producing enzymes capable of inactivating these antibiotics, β-lactamases. This can be prevented by combining the antibiotic with a compound able to inhibit the bacterial enzyme. AimThe aim of this project was to find new β-lactamase inhibitors. To achieve this a large botanical extract library was…
- Read more about the treatment of urinary tract infections (UTIs) without signs of tissue invasion (afebrile UTI (a-UTI)) in men in general practice
- This project develops an accurate screening and surveillance of yeasts to be prepared for the emergence of Candida auris.
- In this controlled study the acceptability, utility and feasibility of self-swabbing instead of physician-swabbing will be evaluated.
- Vancomycin-resistant Enterococcus faecium (VRE) is a multi-resistant bacterium, capable of causing outbreaks in hospitals. This project aims to determine the best VRE screening protocol.
