Search on ZonMw
Search on the website
Filters
830
results
- Read how is investigated wastewater treatment plant employees and local residents are more likely to carry antibiotic-resistant bacteria.
- Methicillin-resistant Staphylococcus aureus (MRSA) is characterised by clonal spread. MRSA clones are unequally distributed across the world and different clones are dominant at different times. AimThe MACOTRA project studied the interaction between MRSA, humans and the environment. The researchers used mathematical models to gain a better understanding of MRSA dynamics.ResultsA main predictor of…
- Hospital-acquired infections, including Multidrug-resistant Enterobacteriaceae (MDR-E), are recognised to be an important public health issue and cause significant burden on health care systems worldwide. While classic infection control strategies mainly target the spread of these pathogens at intra-hospital level (inside a hospital), inter-hospital (between various hospitals and health care…
- Read how this project gained more insight into the resistance mechanisms of pneumococci, particularly the environmental, immunological and pharmacological factors.
- Bacteria are increasingly becoming resistant to antibiotics. This is an immediate threat to health care in the Netherlands and elsewhere. Recent studies show that, in Europe alone, more than 30.000 individuals die every year due to an infection with an antibiotic-resistant bacterium.AimThis project studied the pathways by which resistant bacteria can emerge in complex ecosystems, in which they can…
- Urgent action is required to stem the spread of antimicrobial resistance (AMR). However, because the pace of novel drug development lags behind the evolution of novel AMR determinants, new strategies of containment are required.MethodIn this multinational project proposal, researchers have worked on a resistance-reversal strategy based on the concept of collateral sensitivity (CS). CS between a…
- Infections with antibiotic resistant bacteria, for example an urinary tract infections, are difficult to treat. Because of this, antibiotic resistance is an important public health threat. In Europe, the ESBL-producing gut bacteria (ESBL-G), are the most important cause of such infections, with around 400.000 cases per year. 5% of the Dutch inhabitants carries ESBL-G, while outside the Netherlands…
- The rapid spread of multidrug resistant bacteria threatens the treatment of even simple infections in the near future. However, little is known about how bacteria develop resistance on surfaces.AimThe aim of this project was to investigate fundamental mechanisms that shape antimicrobial resistance in biofilms in relation to the surface and then translate those findings into clinical practice…
- Resistance to antibiotics is increasing worldwide and alternatives are sought for antimicrobial treatment. AimThe overall purpose was to explore and identify antibiotics and non-antibiotics more active in combination than alone (called synergism) against multi- drug resistant bacteria. The tasks of the EMC involved the overall coordination of the project, identification of synergistic combinations…
- Respiratory tract infections are common and are increasingly caused by bacteria that are no longer sensitive to commonly used antibiotics.ObjectiveThis project aimed to expand the therapeutic arsenal against respiratory tract infections by testing agents that stimulate the immune system.ResultsThe AMC had 2 specific tasks. First, a culture system of human respiratory epithelial cells was set up…
- Project descriptionMycobacterium tuberculosis is the causative agent of tuberculosis (TB), a disease responsible for almost 1.5 million deaths per year. In recent years, different classes of drug resistant strains have emerged, making the discovery of novel tuberculostatic drugs a major priority. A major disadvantage of most existing and new TB compounds is that they target a single molecule…
- Policies to address physical inactivity, unhealthy diets and sedentary behaviour can affect the health and well-being of many people. However, it was unknown what policy measures had been implemented in Europe, what their effect is on lifestyle behaviours, and what the consequences are for socio-economic health inequalities. Also, there had not yet been a systematic study of how policy…